Linked Life Data

2424863

Source:http://linkedlifedata.com/resource/pubmed/id/2424863

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1986-8-8
pubmed:abstractText
Proteins synthesized in retinal ganglion cells were labeled with 35S-methionine or 3H-leucine to the vitreous cavity, and the components of fast axonally transported proteins were studied in 20 nerves of 10 normal rabbits and 34 nerves of 17 alloxan-induced diabetic rabbits. Proteins in the optic nerves were separated by SDS-polyacrylamide gel electrophoresis, and axonally transferred proteins were studied by fluorography. In diabetic animals, the axonally transported radioactivity was one-fifth that of the controls. In the fluorographic spectrum of 35S-methionine-labeled proteins, relative proportion of 120kDalton(D)-proteins were increased by 43%, and 29kD proteins were decreased by 65% in diabetic rabbits. Relative proportion of other proteins, such as 24k, 36k, 68k, 150k and 180kD, were the same in control and diabetic rabbits. The quantitative reduction and change in spectrum of fast axonally transported proteins are compatible with the vulnerability and dysfunctions of nerve fibers in diabetic patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0146-0404
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1115-22
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Changes in components of fast axonally transported proteins in the optic nerves of diabetic rabbits.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't