Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1986-7-9
pubmed:databankReference
pubmed:abstractText
Pancreatic amylase, chymotrypsin B, and trypsin I genes are specifically expressed in the exocrine pancreas. The 5'-flanking regions of these genes direct preferential expression of a linked reporter function (chloramphenicol acetyltransferase) in the pancreatic exocrine cell line AR4-2J. The sequences upstream of the amylase and chymotrypsin genes that are required for this cell specific activity possess the characteristics of transcriptional enhancers. We have mapped the regions responsible for enhancer activity by deletion analysis. Modification of specific nucleotide sequences within these regions can alter or eliminate enhancer function. Comparison of the 5'-flanking regions of nine genes expressed in the exocrine pancreas identifies a family of short related sequences. These sequences are located within the enhancer regions that we have mapped and may play a role in the regulation of the expression of pancreatic exocrine-specific genes.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2424007-10872333, http://linkedlifedata.com/resource/pubmed/commentcorrection/2424007-2417232, http://linkedlifedata.com/resource/pubmed/commentcorrection/2424007-3844051, http://linkedlifedata.com/resource/pubmed/commentcorrection/2424007-3904002, http://linkedlifedata.com/resource/pubmed/commentcorrection/2424007-4705382, http://linkedlifedata.com/resource/pubmed/commentcorrection/2424007-503234, http://linkedlifedata.com/resource/pubmed/commentcorrection/2424007-6087163, http://linkedlifedata.com/resource/pubmed/commentcorrection/2424007-6094547, http://linkedlifedata.com/resource/pubmed/commentcorrection/2424007-6094548, http://linkedlifedata.com/resource/pubmed/commentcorrection/2424007-6096017, http://linkedlifedata.com/resource/pubmed/commentcorrection/2424007-6142531, http://linkedlifedata.com/resource/pubmed/commentcorrection/2424007-6209274, http://linkedlifedata.com/resource/pubmed/commentcorrection/2424007-6258156, http://linkedlifedata.com/resource/pubmed/commentcorrection/2424007-6277502, http://linkedlifedata.com/resource/pubmed/commentcorrection/2424007-6294651, http://linkedlifedata.com/resource/pubmed/commentcorrection/2424007-6297796, http://linkedlifedata.com/resource/pubmed/commentcorrection/2424007-6308429, http://linkedlifedata.com/resource/pubmed/commentcorrection/2424007-6358900, http://linkedlifedata.com/resource/pubmed/commentcorrection/2424007-6409417, http://linkedlifedata.com/resource/pubmed/commentcorrection/2424007-6409419, http://linkedlifedata.com/resource/pubmed/commentcorrection/2424007-6419128, http://linkedlifedata.com/resource/pubmed/commentcorrection/2424007-6960240, http://linkedlifedata.com/resource/pubmed/commentcorrection/2424007-7357599
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
83
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3599-603
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Cell-specific enhancers in the rat exocrine pancreas.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't