Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1986-7-18
pubmed:abstractText
A protein exhibiting immunochemical cross-reactivity with the murine alpha 1-pregnancy-associated protein (alpha 1-PAP) has been detected in the sera of female rats. The protein has an alpha 1-electrophoretic mobility, an estimated molecular weight of 150,000 and is readily detectable in the sera of nonpregnant female rats of each strain examined. During pregnancy, the serum concentration increases up to five-fold, reaching maximal levels at the same gestational stage as alpha 1-PAP in the mouse. Immunohistochemical studies revealed a staining pattern for the rat protein similar to that seen for alpha 1-PAP in the mouse, with positive cells being observed in lumbar lymph nodes, the lamina propria of gut mucosa, Peyer's patches, intracellularly in some hepatocytes and, during pregnancy, also in the placenta and metrial gland. On the basis of these immunochemical, physicochemical and immunohistochemical findings, it is proposed that the protein detected in rat sera represents the analogue of the murine alpha 1-PAP, and that the rat strains examined more closely resemble high endogenous alpha 1-PAP-producer mouse strains. It is proposed that alpha 1-PAP, and a number of other rodent pregnancy proteins recently described, may be used in functional studies of human alpha 2-PAG.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2423447-2412747, http://linkedlifedata.com/resource/pubmed/commentcorrection/2423447-2419555, http://linkedlifedata.com/resource/pubmed/commentcorrection/2423447-370031, http://linkedlifedata.com/resource/pubmed/commentcorrection/2423447-6189935, http://linkedlifedata.com/resource/pubmed/commentcorrection/2423447-6202814, http://linkedlifedata.com/resource/pubmed/commentcorrection/2423447-6218299, http://linkedlifedata.com/resource/pubmed/commentcorrection/2423447-630589, http://linkedlifedata.com/resource/pubmed/commentcorrection/2423447-6456343, http://linkedlifedata.com/resource/pubmed/commentcorrection/2423447-6483814, http://linkedlifedata.com/resource/pubmed/commentcorrection/2423447-6513499, http://linkedlifedata.com/resource/pubmed/commentcorrection/2423447-6576330, http://linkedlifedata.com/resource/pubmed/commentcorrection/2423447-6600258, http://linkedlifedata.com/resource/pubmed/commentcorrection/2423447-6699817, http://linkedlifedata.com/resource/pubmed/commentcorrection/2423447-6950820, http://linkedlifedata.com/resource/pubmed/commentcorrection/2423447-6977028, http://linkedlifedata.com/resource/pubmed/commentcorrection/2423447-70291, http://linkedlifedata.com/resource/pubmed/commentcorrection/2423447-7126157, http://linkedlifedata.com/resource/pubmed/commentcorrection/2423447-7329816, http://linkedlifedata.com/resource/pubmed/commentcorrection/2423447-7429885, http://linkedlifedata.com/resource/pubmed/commentcorrection/2423447-87341
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0019-2805
pubmed:author
pubmed:issnType
Print
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
303-9
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:2423447-Animals, pubmed-meshheading:2423447-Chromatography, Gel, pubmed-meshheading:2423447-Cross Reactions, pubmed-meshheading:2423447-Female, pubmed-meshheading:2423447-Histocytochemistry, pubmed-meshheading:2423447-Immunoelectrophoresis, Two-Dimensional, pubmed-meshheading:2423447-Immunoenzyme Techniques, pubmed-meshheading:2423447-Intestines, pubmed-meshheading:2423447-Liver, pubmed-meshheading:2423447-Lymph Nodes, pubmed-meshheading:2423447-Metrial Gland, pubmed-meshheading:2423447-Mice, pubmed-meshheading:2423447-Mice, Inbred C57BL, pubmed-meshheading:2423447-Molecular Weight, pubmed-meshheading:2423447-Peyer's Patches, pubmed-meshheading:2423447-Placenta, pubmed-meshheading:2423447-Pregnancy, pubmed-meshheading:2423447-Pregnancy Proteins, pubmed-meshheading:2423447-Pregnancy-Associated Plasma Protein-A, pubmed-meshheading:2423447-Rats, pubmed-meshheading:2423447-Rats, Inbred Strains
pubmed:year
1986
pubmed:articleTitle
Detection and immunohistochemical localization of alpha 1-pregnancy-associated protein (alpha 1-PAP) in rats.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't