Linked Life Data

2422951

Source:http://linkedlifedata.com/resource/pubmed/id/2422951

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5 Pt 1
pubmed:dateCreated
1986-6-18
pubmed:abstractText
Amylase secretion by fetal and newborn rat pancreata was shown not to respond to cholecystokinin (CCK) stimulation. Binding of 125I-Bolton-Hunter (125I-BH)-CCK-8 to dispersed pancreatic acini from rats at various perinatal ages was measured and compared with adults. Binding occurred maximally at 30 min at 37 degrees C at all ages. Maximal binding increased with age. The capacity and affinity of the CCK-receptor binding system was analyzed by Scatchard's method. The results revealed that the capacity of the high-affinity component gradually increases with age, whereas that of the low-affinity component remains relatively constant. Amylase secretion due to CCK stimulation also increases with age, suggesting that the lack of responsiveness of pancreata of pups to secretagogue is due to a low binding capacity of the high-affinity component of the receptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
250
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
G594-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Maturation of cholecystokinin receptors in pancreatic acini of rats.
pubmed:publicationType
Journal Article, Comparative Study