Linked Life Data

2422859

Source:http://linkedlifedata.com/resource/pubmed/id/2422859

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1986-6-10
pubmed:abstractText
In seven patients with severe atopic dermatitis (AD) we investigated the 45Ca-efflux responses from prelabelled neutrophils stimulated with the chemotactic peptide formyl-methionyl-leucyl-phenylalanine (F-Met-Leu-Phe) and catecholamines. We found no difference between the burst in 45Ca-efflux induced by F-Met-leu-Phe in AD patients when comparing with controls. Alpha 1-receptor responses are believed to be mediated by a calcium mechanism and like normal cells the 45Ca-efflux rate in AD neutrophils was unchanged both after stimulation with alpha- and beta-receptor agonists. Whereas the cAMP-hyporesponsiveness of beta-adrenergic receptors is known in atopic disease our present study might indicate a normal alpha-adrenergic response in AD neutrophils.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0365-8341
pubmed:author
pubmed:issnType
Print
pubmed:volume
120
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
50-2
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Calcium efflux changes in neutrophils from patients with severe atopic dermatitis.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't