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rdf:type |
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lifeskim:mentions |
umls-concept:C0003410,
umls-concept:C0015982,
umls-concept:C0016006,
umls-concept:C0030685,
umls-concept:C0030956,
umls-concept:C0150312,
umls-concept:C0330390,
umls-concept:C0391871,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1963578
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pubmed:issue |
1
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pubmed:dateCreated |
1986-6-16
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pubmed:abstractText |
When Glu-plasminogen (plg) was activated by urokinase (UK) in the presence of fibrinogen or fibrin, B beta peptides (B beta 1-42) were released faster from fibrinogen than from fibrin (B beta 15-42). These results were contrary to faster release of B beta 15-42 from fibrin in the UK-activated clotted plasma in comparison to the release of B beta 1-42 from UK-activated plasma. The addition of plasma or lysine-Sepharose pass through fraction to the above system resulted in faster release of B beta peptides from fibrin than fibrinogen. The addition of alpha 2 antiplasmin (alpha 2AP) to the mixture of Glu-pig, UK and fibrinogen or fibrin resulted in faster release of B beta peptides from fibrin than from fibrinogen. These results indicate that fibrin protected plasmin from inactivation by alpha 2AP, leading to cleavage of Arg(42)-Ala(43) bond in beta-chain of fibrin which seems to be less susceptible to plasmin than the same bond in fibrinogen.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Fibrin,
http://linkedlifedata.com/resource/pubmed/chemical/Fibrin Fibrinogen Degradation...,
http://linkedlifedata.com/resource/pubmed/chemical/Fibrinogen,
http://linkedlifedata.com/resource/pubmed/chemical/Fibrinolysin,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Plasminogen,
http://linkedlifedata.com/resource/pubmed/chemical/Sepharose,
http://linkedlifedata.com/resource/pubmed/chemical/Urokinase-Type Plasminogen Activator,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-2-Antiplasmin,
http://linkedlifedata.com/resource/pubmed/chemical/fibrinogen Bbeta (1-42),
http://linkedlifedata.com/resource/pubmed/chemical/fibrinogen Bbeta (15-42),
http://linkedlifedata.com/resource/pubmed/chemical/lysine-sepharose,
http://linkedlifedata.com/resource/pubmed/chemical/lysyl-plasminogen
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0049-3848
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
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pubmed:year |
1986
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pubmed:articleTitle |
Release of B beta peptides from fibrinogen or fibrin in the presence of alpha 2 antiplasmin.
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pubmed:publicationType |
Journal Article,
In Vitro
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