Linked Life Data

2422726

Source:http://linkedlifedata.com/resource/pubmed/id/2422726

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1986-6-23
pubmed:abstractText
The relationship between alpha-fetoprotein (AFP) content and phases of the cell cycle was investigated by simultaneous flow cytometric analysis of cellular DNA and AFP, using an AFP producing human hepatoma cell line (HuH-7). AFP content was evaluated by measuring fluorescence intensity of FITC after staining the cells with an indirect immunofluorescent method, and DNA content by fluorescence intensity of propidium iodide. The amount of intracellular AFP was highly variable but flow cytometric analysis produced a distinct profile. AFP content increased linearly with progression of the cell cycle, except for a modest dip in the early S phase. This suggests that AFP production and secretion are closely linked to the cell cycle.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1010-4283
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
483-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Change of alpha-fetoprotein content during cell cycle of human hepatoma cells in vitro: flow cytometric analysis.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't