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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1986-6-17
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pubmed:abstractText |
Bilateral microinjections of 6-hydroxydopamine (6-OHDA) into the nuclei loci coerulei (LC) of male Wistar rats resulted in significant depletion of mesencephalic and striatal norepinephrine, accompanied by a small reduction in dopamine content only in the striatum. Apomorphine (2.5 mg/kg IP) induced marked aggression consisting of prolonged posturing, vocalization and attacks only in 6-OHDA lesioned animals. Biochemical analysis revealed that 6-OHDA antagonized the ability of apomorphine to raise the serotonin concentration in the striatum. It is concluded that the LC neurons play an inhibitory role in apomorphine-induced aggressiveness and the involvement of serotonergic neurons is suggested.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0091-3057
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
773-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2422669-Aggression,
pubmed-meshheading:2422669-Animals,
pubmed-meshheading:2422669-Apomorphine,
pubmed-meshheading:2422669-Biogenic Amines,
pubmed-meshheading:2422669-Hydroxydopamines,
pubmed-meshheading:2422669-Hydroxyindoleacetic Acid,
pubmed-meshheading:2422669-Injections,
pubmed-meshheading:2422669-Locus Coeruleus,
pubmed-meshheading:2422669-Male,
pubmed-meshheading:2422669-Oxidopamine,
pubmed-meshheading:2422669-Rats,
pubmed-meshheading:2422669-Rats, Inbred Strains
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pubmed:year |
1986
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pubmed:articleTitle |
Effect of 6-OHDA injected into the locus coeruleus on apomorphine-induced aggression.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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