| pubmed-article:2422659 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2422659 | lifeskim:mentions | umls-concept:C0086427 | lld:lifeskim |
| pubmed-article:2422659 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2422659 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:2422659 | lifeskim:mentions | umls-concept:C0003250 | lld:lifeskim |
| pubmed-article:2422659 | lifeskim:mentions | umls-concept:C1422036 | lld:lifeskim |
| pubmed-article:2422659 | lifeskim:mentions | umls-concept:C0439851 | lld:lifeskim |
| pubmed-article:2422659 | lifeskim:mentions | umls-concept:C1552596 | lld:lifeskim |
| pubmed-article:2422659 | lifeskim:mentions | umls-concept:C1947931 | lld:lifeskim |
| pubmed-article:2422659 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:2422659 | pubmed:dateCreated | 1986-5-23 | lld:pubmed |
| pubmed-article:2422659 | pubmed:abstractText | We report the production and characterization of a human monoclonal antibody reactive against the major envelope glycoprotein of human T-cell leukemia virus type I (HTLV-I), a virus linked to the etiology of adult T-cell leukemia. We exposed lymph-node cells derived from a patient with adult T-cell leukemia to the Epstein-Barr virus in vitro and obtained a B-cell clone (designated 0.5 alpha) by a limiting dilution technique. The secreted product of 0.5 alpha is a monoclonal antibody (also designated 0.5 alpha; that is IgG1 and has kappa light chains) that binds to the cell membrane of T-cells infected with HTLV-I and lyses them in the presence of complement. The antibody does not react with HTLV-I-negative T cells. In electroblot assays, the monoclonal antibody detects a 46-kDa glycoprotein in disrupted HTLV-I virions and a 34-kDa product following digestion of the viral protein with endoglycosidase F. These molecules have been reported to represent the HTLV-I env gene products. The antibody does not react with HTLV-II and HTLV-III virions. Glycoproteins of 61 and 68 kDa, which are known to be encoded at least in part by the env gene of HTLV-I, are precipitated by the antibody from endogenously radiolabeled HTLV-I-infected HUT 102-B2 and MT-2 cells, respectively. These results suggest that this human monoclonal antibody reacts with an env-encoded glycoprotein of HTLV-I. By using a competition assay with a biotin-labeled 0.5 alpha antibody, we observed that 15 out of 15 patients with adult T-cell leukemia had antibodies that block binding of the 0.5 alpha antibody to HTLV-I virions. This suggests that the antigen detected by 0.5 alpha antibody is a common epitope recognized in HTLV-I-infected individuals in vivo. This antibody, as well as the general strategy for making human monoclonal antibodies reactive against pathogenic retroviruses, may have diagnostic or therapeutic application. | lld:pubmed |
| pubmed-article:2422659 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422659 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422659 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422659 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422659 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422659 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422659 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422659 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422659 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422659 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422659 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422659 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422659 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422659 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422659 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422659 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422659 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422659 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422659 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422659 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422659 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422659 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422659 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422659 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422659 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422659 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422659 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422659 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2422659 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422659 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2422659 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422659 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422659 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422659 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422659 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422659 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2422659 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2422659 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:2422659 | pubmed:author | pubmed-author:Robert-Guroff... | lld:pubmed |
| pubmed-article:2422659 | pubmed:author | pubmed-author:BroderSS | lld:pubmed |
| pubmed-article:2422659 | pubmed:author | pubmed-author:CossmanJJ | lld:pubmed |
| pubmed-article:2422659 | pubmed:author | pubmed-author:MatsushitaSS | lld:pubmed |
| pubmed-article:2422659 | pubmed:author | pubmed-author:MitsuyaHH | lld:pubmed |
| pubmed-article:2422659 | pubmed:author | pubmed-author:TrepelJJ | lld:pubmed |
| pubmed-article:2422659 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2422659 | pubmed:volume | 83 | lld:pubmed |
| pubmed-article:2422659 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2422659 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2422659 | pubmed:pagination | 2672-6 | lld:pubmed |
| pubmed-article:2422659 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:2422659 | pubmed:meshHeading | pubmed-meshheading:2422659-... | lld:pubmed |
| pubmed-article:2422659 | pubmed:meshHeading | pubmed-meshheading:2422659-... | lld:pubmed |
| pubmed-article:2422659 | pubmed:meshHeading | pubmed-meshheading:2422659-... | lld:pubmed |
| pubmed-article:2422659 | pubmed:meshHeading | pubmed-meshheading:2422659-... | lld:pubmed |
| pubmed-article:2422659 | pubmed:meshHeading | pubmed-meshheading:2422659-... | lld:pubmed |
| pubmed-article:2422659 | pubmed:meshHeading | pubmed-meshheading:2422659-... | lld:pubmed |
| pubmed-article:2422659 | pubmed:meshHeading | pubmed-meshheading:2422659-... | lld:pubmed |
| pubmed-article:2422659 | pubmed:meshHeading | pubmed-meshheading:2422659-... | lld:pubmed |
| pubmed-article:2422659 | pubmed:meshHeading | pubmed-meshheading:2422659-... | lld:pubmed |
| pubmed-article:2422659 | pubmed:meshHeading | pubmed-meshheading:2422659-... | lld:pubmed |
| pubmed-article:2422659 | pubmed:meshHeading | pubmed-meshheading:2422659-... | lld:pubmed |
| pubmed-article:2422659 | pubmed:meshHeading | pubmed-meshheading:2422659-... | lld:pubmed |
| pubmed-article:2422659 | pubmed:meshHeading | pubmed-meshheading:2422659-... | lld:pubmed |
| pubmed-article:2422659 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:2422659 | pubmed:articleTitle | Human monoclonal antibody directed against an envelope glycoprotein of human T-cell leukemia virus type I. | lld:pubmed |
| pubmed-article:2422659 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2422659 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2422659 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2422659 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2422659 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2422659 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2422659 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2422659 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2422659 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2422659 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2422659 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2422659 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2422659 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2422659 | lld:pubmed |
