Linked Life Data

2422557

Source:http://linkedlifedata.com/resource/pubmed/id/2422557

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6065
pubmed:dateCreated
1986-6-12
pubmed:abstractText
Segregation of voltage-dependent sodium channels to the hillock of motoneurones and nodes of Ranvier in myelinated axons is crucial for conduction of the nerve impulse. Much less is known, however, about the distribution of voltage-dependent Na+ channels on muscle fibres. Recently, Beam et al. have shown that Na+ channels are concentrated near the neuromuscular junction. To determine the topography and mechanisms governing the distribution of voltage-dependent Na+ channels on muscle, microfluorimetry and fluorescence photobleach recovery (FPR) have now been used to measure the density and lateral mobility of fluorescently labelled Na+ channels on uninnervated and innervated muscle fibres. On uninnervated myotubes, Na+ channels are diffusely distributed and freely mobile, whereas after innervation the channels concentrate at neuronal contact sites. These channels are immobile and co-localize with acetylcholine receptors (AChRs). At extrajunctional regions the Na+ channel density is lower and the channels more mobile. The results suggest that the nerve induces Na+ channels to redistribute, immobilize and co-localize with AChRs at sites of neuronal contact.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:volume
321
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
63-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Fluorescently labelled Na+ channels are localized and immobilized to synapses of innervated muscle fibres.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't