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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1986-5-14
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pubmed:abstractText |
Nerve growth factor (NGF) induces degranulation of rat peritoneal mast cells (RPMC) in a dose-dependent manner, providing direct evidence for its action on non-neuronal tissues. Activation of RPMC by NGF depends on lysophosphatidylserine and extracellular calcium. NGF-mediated RPMC degranulation is not coupled to a transient increase in intracellular free calcium ([Ca2+]i). It is suggested that NGF has a unique mode of action independent of [Ca2+]i and presumably also without involving protein kinase C activation as indicated by the effects of phorbol esters and NGF on antigen-evoked [Ca2+]i rise.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
31
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pubmed:volume |
198
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
315-20
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2420641-Animals,
pubmed-meshheading:2420641-Calcium,
pubmed-meshheading:2420641-Dose-Response Relationship, Drug,
pubmed-meshheading:2420641-Histamine Release,
pubmed-meshheading:2420641-Lysophospholipids,
pubmed-meshheading:2420641-Male,
pubmed-meshheading:2420641-Mast Cells,
pubmed-meshheading:2420641-Nerve Growth Factors,
pubmed-meshheading:2420641-Phosphatidylserines,
pubmed-meshheading:2420641-Rats,
pubmed-meshheading:2420641-Rats, Inbred Strains,
pubmed-meshheading:2420641-Tetradecanoylphorbol Acetate
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pubmed:year |
1986
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pubmed:articleTitle |
Nerve growth factor induces mast cell degranulation without changing intracellular calcium levels.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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