Linked Life Data

2419411

Source:http://linkedlifedata.com/resource/pubmed/id/2419411

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1986-4-1
pubmed:abstractText
Peripheral blood leukocytes (PBL) from noninstitutionalized individuals with trisomy 21, paired with closely age-matched and/or family members as controls, were analyzed for different aspects of their cellular and humoral immune responses, and were phenotypically characterized by means of various monoclonal antibodies. Both the in vitro PBL proliferative and antibody responses to a bacterial antigen (tetanus toxoid) and to viral antigens (influenza A/Bangkok and B/Singapore) were significantly decreased in trisomy 21. In addition, bacterial and viral antigen-induced in vitro interleukin 2 (IL 2) production was markedly reduced, although mitogen (PHA)-stimulated IL 2 production was not impaired. The functional abnormalities observed in trisomy 21 PBL occur concomitantly with numerical alterations in circulating lymphocyte subsets in these same individuals. Although no difference was observed between the trisomic and control groups in the percentage of total T and B lymphocytes, a decreased level of Leu-3a + 3b-positive cells (T helper/inducer cells) and an increased level of Leu-2a-positive cells (T suppressor/cytotoxic cells) that co-expressed Leu-15 (suppressor alone) were noted.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
136
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1661-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Abnormalities of the in vitro cellular and humoral responses to tetanus and influenza antigens with concomitant numerical alterations in lymphocyte subsets in Down syndrome (trisomy 21).
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't