| pubmed-article:2418832 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2418832 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:2418832 | lifeskim:mentions | umls-concept:C0521390 | lld:lifeskim |
| pubmed-article:2418832 | lifeskim:mentions | umls-concept:C0006685 | lld:lifeskim |
| pubmed-article:2418832 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2418832 | lifeskim:mentions | umls-concept:C0598352 | lld:lifeskim |
| pubmed-article:2418832 | lifeskim:mentions | umls-concept:C0682770 | lld:lifeskim |
| pubmed-article:2418832 | lifeskim:mentions | umls-concept:C0220821 | lld:lifeskim |
| pubmed-article:2418832 | lifeskim:mentions | umls-concept:C0332324 | lld:lifeskim |
| pubmed-article:2418832 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2418832 | pubmed:dateCreated | 1986-3-21 | lld:pubmed |
| pubmed-article:2418832 | pubmed:abstractText | The effect of dihydropyridine agonists and antagonists on neuronal voltage sensitive calcium channels was investigated. The resting intracellular calcium concentration of synaptosomes prepared from whole brain was 110 +/- 9 nM, as assayed by the indicator quin 2. Depolarisation of the synaptosomes with K+ produced an immediate increase in [Ca2+]i. The calcium agonist Bay K 8644 and antagonist nifedipine did not affect [Ca2+]i under resting or depolarising conditions. In addition, K+ stimulated 45Ca2+ uptake into synaptosomes prepared from the hippocampus was insensitive to Bay K 8644 and PY 108-068 in normal or Na+ free conditions. In neuronally derived NG108-15 cells the enantiomers of the dihydropyridine derivative 202-791 showed opposite effects in modulating K+ stimulated 45Ca2+ uptake. (-)-R-202-791 inhibited K+ induced 45Ca2+ uptake with an IC50 of 100 nM and (+)-S-202-791 enhanced K+ stimulated uptake with an EC50 of 80 nM. These results suggest that synaptosomal voltage sensitive calcium channels either are of a different type to those found in peripheral tissues and cells of neural origin or that expression of functional effects of dihydropyridines requires different experimental conditions to those used here. | lld:pubmed |
| pubmed-article:2418832 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2418832 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2418832 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2418832 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2418832 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:2418832 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:2418832 | pubmed:author | pubmed-author:KarobathMM | lld:pubmed |
| pubmed-article:2418832 | pubmed:author | pubmed-author:CrebaJ AJA | lld:pubmed |
| pubmed-article:2418832 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2418832 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:2418832 | pubmed:volume | 134 | lld:pubmed |
| pubmed-article:2418832 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2418832 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2418832 | pubmed:pagination | 1038-47 | lld:pubmed |
| pubmed-article:2418832 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:2418832 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:2418832 | pubmed:articleTitle | The effect of dihydropyridine calcium agonists and antagonists on neuronal voltage sensitive calcium channels. | lld:pubmed |
| pubmed-article:2418832 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2418832 | pubmed:publicationType | In Vitro | lld:pubmed |
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