| pubmed-article:2418442 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2418442 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2418442 | lifeskim:mentions | umls-concept:C0567416 | lld:lifeskim |
| pubmed-article:2418442 | lifeskim:mentions | umls-concept:C0009013 | lld:lifeskim |
| pubmed-article:2418442 | lifeskim:mentions | umls-concept:C0019721 | lld:lifeskim |
| pubmed-article:2418442 | lifeskim:mentions | umls-concept:C0003316 | lld:lifeskim |
| pubmed-article:2418442 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:2418442 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:2418442 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2418442 | pubmed:dateCreated | 1986-3-14 | lld:pubmed |
| pubmed-article:2418442 | pubmed:abstractText | Polyclonal reagents have been used to define HLA class II molecules in conventional serologic and cellular typing. We generated human alloreactive T-cell clones to analyze the functional fine specificities of HLA class II molecules that might be important for the phenomenon of HLA and disease association. We chose to examine HLA-Dw14, an HLA-D specificity that has been associated with juvenile rheumatoid arthritis. In this paper we have presented data that suggest that conventional cellular typing does not reflect the distribution of T-cell epitopes on major histocompatibility complex class II molecules. We describe three alloreactive T-cell clones that have defined three separate Dw14-associated T-cell epitopes. Two of these epitopes were on a DR-region molecule; the third was located on a DQ-region product. In a panel of unrelated DR4-positive donors, these three DW14-associated determinants were present in a high frequency but were not linked to each other. Within the tested panel of DR4-positive cells, all possible combinatorial arrangements of these three allodeterminants were seen. The concurrent expression of any two of the three allodeterminants was equivalent to a positive typing response for Dw14. Our finding that HLA-Dw14 is not characterized by a unique allodeterminant but by the combinatorial recognition of independently distributed T-cell interaction sites suggests that analysis of HLA and disease association may be more clearly demonstrated through the use of human T-cell clones. | lld:pubmed |
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| pubmed-article:2418442 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2418442 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2418442 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2418442 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2418442 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2418442 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2418442 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2418442 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:2418442 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:2418442 | pubmed:author | pubmed-author:FathmanC GCG | lld:pubmed |
| pubmed-article:2418442 | pubmed:author | pubmed-author:GoronzyJJ | lld:pubmed |
| pubmed-article:2418442 | pubmed:author | pubmed-author:WeyandC MCM | lld:pubmed |
| pubmed-article:2418442 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2418442 | pubmed:volume | 83 | lld:pubmed |
| pubmed-article:2418442 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2418442 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2418442 | pubmed:pagination | 762-6 | lld:pubmed |
| pubmed-article:2418442 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:2418442 | pubmed:meshHeading | pubmed-meshheading:2418442-... | lld:pubmed |
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| pubmed-article:2418442 | pubmed:meshHeading | pubmed-meshheading:2418442-... | lld:pubmed |
| pubmed-article:2418442 | pubmed:meshHeading | pubmed-meshheading:2418442-... | lld:pubmed |
| pubmed-article:2418442 | pubmed:meshHeading | pubmed-meshheading:2418442-... | lld:pubmed |
| pubmed-article:2418442 | pubmed:meshHeading | pubmed-meshheading:2418442-... | lld:pubmed |
| pubmed-article:2418442 | pubmed:meshHeading | pubmed-meshheading:2418442-... | lld:pubmed |
| pubmed-article:2418442 | pubmed:meshHeading | pubmed-meshheading:2418442-... | lld:pubmed |
| pubmed-article:2418442 | pubmed:meshHeading | pubmed-meshheading:2418442-... | lld:pubmed |
| pubmed-article:2418442 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:2418442 | pubmed:articleTitle | Human T-cell clones used to define functional epitopes on HLA class II molecules. | lld:pubmed |
| pubmed-article:2418442 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2418442 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2418442 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2418442 | lld:pubmed |
