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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1986-3-21
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pubmed:databankReference |
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pubmed:abstractText |
A keratin set which consists of a type I 47kd and a type II 57kd protein occurs as a major constituent of the keratin patterns of various internal stratified epithelia of the mouse. We have isolated specific cDNA clones of the two complementary keratin subunits from a cDNA library constructed with polyA+RNA of mouse tongue epithelium and present the complete nucleotide and deduced amino acid sequences of the 57kd protein and about 75% of the corresponding data of the 47kd protein. The comparison of the sequence data with those of known epidermal keratin mRNAs coding for the two types of keratin proteins reveals a fundamentally identical and type-specific organization of the mRNAs into both highly conserved and variable domains. In order to avoid cross-reactions with other members of the keratin multigene family, appropriately taylored 35S-labeled cDNA probes comprising the low and non-homologous 3' coding and noncoding domains of the mRNAs were used for in situ hybridization to tissue sections. The localization and distribution of the corresponding transcripts indicates a strongly compartmentalized keratin expression in mouse tongue epithelium.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-1105573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-1259158,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-2410904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-2416562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-2580298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-2580302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-2581944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-2581964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-262423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-380653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-3889842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-581264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-6084625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-6113054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-6159641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-6161811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-6169442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-6174226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-6183000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-6186379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-6186381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-6186388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-6188955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-6190956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-6191871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-6195160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-6196784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-6202418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-6203802,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-6204990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-6207530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-6209405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-6210150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-6278404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-6310323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-642007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-662001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-7049531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-75887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-77738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-787937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-881736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2418416-886619
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0305-1048
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
751-63
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2418416-Amino Acid Sequence,
pubmed-meshheading:2418416-Animals,
pubmed-meshheading:2418416-Base Sequence,
pubmed-meshheading:2418416-Cloning, Molecular,
pubmed-meshheading:2418416-DNA,
pubmed-meshheading:2418416-Epithelium,
pubmed-meshheading:2418416-Genes,
pubmed-meshheading:2418416-Keratins,
pubmed-meshheading:2418416-Mice,
pubmed-meshheading:2418416-Molecular Weight,
pubmed-meshheading:2418416-Nucleic Acid Hybridization,
pubmed-meshheading:2418416-Plasmids,
pubmed-meshheading:2418416-Poly A,
pubmed-meshheading:2418416-Protein Biosynthesis,
pubmed-meshheading:2418416-RNA,
pubmed-meshheading:2418416-RNA, Messenger,
pubmed-meshheading:2418416-Tongue,
pubmed-meshheading:2418416-Transcription, Genetic
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pubmed:year |
1986
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pubmed:articleTitle |
Nonepidermal members of the keratin multigene family: cDNA sequences and in situ localization of the mRNAs.
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