Linked Life Data

2417929

Source:http://linkedlifedata.com/resource/pubmed/id/2417929

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1986-2-24
pubmed:abstractText
Peripheral blood and/or bone marrow leukemic cell suspensions from 49 patients with 'non-T, non-B' acute lymphoblastic leukemia (ALL) were analysed by flow cytometry using a new panel of four monoclonal antibodies. Anti-BL1 and anti-BL2 originating from NALM-6 and B35M lymphoblastoid cell lines, respectively. These antibodies recognize B-cell differentiation antigens: a heat stable non-immunoprecipitable antigenic determinant, and a 68 000 daltons glycoprotein molecule, respectively. BL5 and BL6 were derived by immunization with the promyelocytic cell line HL-60, recognizing antigens present on early hematopoietic cells: an 85 000 daltons MW glycoprotein (Pro-Im 1) and a heat stable antigen (Pro-Im2), respectively. All ALL patients studied had L1 or L2 morphology by the FAB classification and a blast count exceeding 50 per cent. There were 25 males and 24 females. Median age was 8 years (range 1-67 years). Thirty-nine cases were studied at initial presentation and 10 at relapse. Cells from 46/49 cases expressed BL2 and/or BL1, but were not reactive with BL5 or BL6. Three of 49 cases did not express BL1 or BL2. However, a small percentage of blasts from one case was positive for BL5 (13 per cent) and the other 2 cases were reactive with BL6 (20 per cent and 36 per cent, respectively). These were one adult and 2 pediatric patients that had other ALL markers and achieved a complete remission with appropriate ALL therapy. One of the BL6+ cases relapsed after 19 months with a change in phenotype to BL1+ BL2+ BL5- BL6-. This analysis shows that the majority of 'non-T, non-B' ALL's do express B-cell associated antigens (BL1/BL2) argumentative of their B-cell origin. A small subgroup does not express such antigens and may arise from a more immature cell, since they expressed antigens on early hematopoietic stem cells.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0278-0232
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
271-81
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:2417929-Adolescent, pubmed-meshheading:2417929-Adult, pubmed-meshheading:2417929-Aged, pubmed-meshheading:2417929-Antibodies, Monoclonal, pubmed-meshheading:2417929-Antigens, Neoplasm, pubmed-meshheading:2417929-B-Lymphocytes, pubmed-meshheading:2417929-Cell Line, pubmed-meshheading:2417929-Cell Separation, pubmed-meshheading:2417929-Child, pubmed-meshheading:2417929-Child, Preschool, pubmed-meshheading:2417929-Epitopes, pubmed-meshheading:2417929-Female, pubmed-meshheading:2417929-Flow Cytometry, pubmed-meshheading:2417929-HLA-DR Antigens, pubmed-meshheading:2417929-Hematopoietic Stem Cells, pubmed-meshheading:2417929-Histocompatibility Antigens Class II, pubmed-meshheading:2417929-Humans, pubmed-meshheading:2417929-Infant, pubmed-meshheading:2417929-Leukemia, Lymphoid, pubmed-meshheading:2417929-Male, pubmed-meshheading:2417929-Middle Aged, pubmed-meshheading:2417929-Neprilysin, pubmed-meshheading:2417929-Phenotype, pubmed-meshheading:2417929-Receptors, Antigen, B-Cell, pubmed-meshheading:2417929-T-Lymphocytes
pubmed:articleTitle
Phenotypic characterization of 'non-T, non-B' acute lymphoblastic leukemia by a new panel (BL) of monoclonal antibodies.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't