Linked Life Data

2417876

Source:http://linkedlifedata.com/resource/pubmed/id/2417876

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1986-3-10
pubmed:abstractText
The effect of hydrocortisone on the growth potential of human and baboon corneal endothelial cells in tissue culture was evaluated. Hydrocortisone-21-sodium succinate was incorporated into growth medium at 10(-3) to 10(-7) M concentrations in a standard tissue culture medium. Inclusion of hydrocortisone into growth medium at higher concentrations (e.g. 10(-4) and 10(-3) M) resulted in a significantly reduced cell growth and a decreased level of DNA synthesis. Higher concentrations of hydrocortisone induced morphological alterations in the corneal endothelial cells in vitro. The incorporation of 5% dextran into the growth medium failed to alter the negative hydrocortisone effects. These experiments suggest the potential adverse effects of hydrocortisone for the corneal endothelium in vitro when used at higher concentrations.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0014-4835
pubmed:author
pubmed:issnType
Print
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
487-95
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Effect of hydrocortisone on corneal endothelial cells in vitro.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't