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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1986-2-19
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pubmed:abstractText |
This paper describes the existence of two pharmacologically distinct types of Ca2+ channels in rat skeletal muscle cells (myoballs) in culture. The first class of Ca2+ channels is insensitive to the dihydropyridine (DHP) (+)-PN 200-110; the second class of Ca2+ channels is blocked by low concentrations of (+)-PN 200-110. The two pharmacologically different Ca2+ channels are also different in their voltage and time dependence. The threshold for activation of the DHP-insensitive Ca2+ channel is near -65 mV, whereas the threshold for activation of the DHP-sensitive Ca2+ channel is near -30 mV. Current flowing through the DHP-insensitive Ca2+ channel is transient with relatively fast kinetics. Half-maximal inactivation for the DHP-insensitive Ca2+ channel is observed at a holding potential Vh0.5 = -78 mV and the channel is completely inactivated at -60 mV. Two different behaviors have been found for DHP-sensitive channels with two different kinetics of inactivation (one being about 16 times faster than the other at -2 mV) and two different voltage dependencies. These two different behaviors are often observed in the same myoball and may correspond to two different subtypes of DHP-sensitive Ca2+ channels or to two different modes of expression of one single Ca2+ channel protein.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417248-1142121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417248-2409515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417248-2409971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417248-2410796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417248-2410797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417248-2410819,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417248-2580308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417248-2580309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417248-2581141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417248-2582115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417248-2997201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417248-309941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417248-4526277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417248-5016370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417248-6087159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417248-6089781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417248-6090646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417248-6146926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417248-6207437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417248-6257898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417248-6258862,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417248-6267261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417248-6270629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417248-6272298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417248-6280075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417248-6304026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417248-6305931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417248-6323901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417248-6487739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417248-7310722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417248-7431249
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
517-21
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2417248-Animals,
pubmed-meshheading:2417248-Barium,
pubmed-meshheading:2417248-Calcium,
pubmed-meshheading:2417248-Cells, Cultured,
pubmed-meshheading:2417248-Cobalt,
pubmed-meshheading:2417248-Dihydropyridines,
pubmed-meshheading:2417248-Electric Conductivity,
pubmed-meshheading:2417248-Ion Channels,
pubmed-meshheading:2417248-Membrane Potentials,
pubmed-meshheading:2417248-Muscles,
pubmed-meshheading:2417248-Pyridines,
pubmed-meshheading:2417248-Rats,
pubmed-meshheading:2417248-Tetrodotoxin
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pubmed:year |
1986
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pubmed:articleTitle |
Different types of Ca2+ channels in mammalian skeletal muscle cells in culture.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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