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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1986-2-12
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pubmed:abstractText |
Phencylidine (PCP) is a major drug of abuse in the United States. It produces a toxic confusional psychosis in man. We show here that nanomolar to micromolar concentrations of PCP and behaviorally active congeners selectively block voltage-regulated noninactivating (or very slowly inactivating) presynaptic K channels in the brain. The rank order of potency for blockage of these K channels parallels both the relative ability of these agents to produce characteristic behavioral deficits in rats and their ability to displace [3H]PCP from its high-affinity binding sites in brain. In view of the enhanced voltage-gated Ca influx that would be expected to accompany blockage of presynaptic K channels, this mechanism could explain the excessive neurotransmitter release that is characteristic of PCP intoxication.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417237-1244891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417237-2580981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417237-2580982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417237-291953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417237-2982106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417237-513116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417237-6111227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417237-6250762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417237-6256770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417237-6278489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417237-6304743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417237-6317114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417237-6602710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417237-7205636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417237-7408426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2417237-79434
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
189-92
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2417237-Animals,
pubmed-meshheading:2417237-Brain,
pubmed-meshheading:2417237-Calcium,
pubmed-meshheading:2417237-Cell Membrane Permeability,
pubmed-meshheading:2417237-Dose-Response Relationship, Drug,
pubmed-meshheading:2417237-Ion Channels,
pubmed-meshheading:2417237-Phencyclidine,
pubmed-meshheading:2417237-Potassium,
pubmed-meshheading:2417237-Radioisotopes,
pubmed-meshheading:2417237-Rats,
pubmed-meshheading:2417237-Rubidium,
pubmed-meshheading:2417237-Synaptosomes
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pubmed:year |
1986
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pubmed:articleTitle |
Phencyclidine in low doses selectively blocks a presynaptic voltage-regulated potassium channel in rat brain.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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