Linked Life Data

2417159

Source:http://linkedlifedata.com/resource/pubmed/id/2417159

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1986-2-7
pubmed:abstractText
The effect of different concentrations (0.001, 0.01, 0.1 and 1 mM) of dopamine on chemo-afferent activity was studied in the rabbit carotid body superfused in vitro. Excitation was the sole effect observed: it was always present for dopamine tests at 0.1 and 1 mM but was found in only 4 out of 9 tests at 0.01 mM and in 1 out of 5 tests at 0.001 mM. By comparison with a natural stimulus like hypoxia, dopamine excitation was delayed and had a much slower time course. Dopamine antagonists, (+)-butaclamol and haloperidol did not affect the responses to dopamine and to hypoxia. The results were not significantly altered when CO2 was added to the superfusing medium. It is concluded that dopamine is not a likely excitatory transmitter for chemoreception in the rabbit carotid body.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0306-4522
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
431-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Effects of dopamine superfusion on the activity of rabbit carotid chemoreceptors in vitro.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't