Linked Life Data

2416685

Source:http://linkedlifedata.com/resource/pubmed/id/2416685

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1986-2-19
pubmed:abstractText
With the aim of elucidating inflammatory reactions in intestinal mucosa evoked by agents of microbial origin, the effect was assessed on intestinal permeability in the rat of two known chemoattractants for granulocytes and macrophages, N-formyl-methionyl-phenylalanine (FMP) and N-formyl-methionyl-leucyl-phenylalanine (FMLP). Fluoresceinated dextran (mol wt 3000 daltons) was used as a permeability marker. It was found that increasing concentrations of FMP enhanced the transmural passage up to a maximum at 2 X 10(-7)-2 X 10(-6)M. With FMLP the effect was greater than with FMP and measurable at 2 X 10(-9)-2 X 10(-8)M. The increased permeability was apparent 1-5 min after introduction of the peptides and prevailed during the 45-min measuring period. The bimodal response to the peptides is discussed in relation to different potential target-effector cells in the intestinal wall.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0360-3997
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
365-73
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Effect of N-formylated methionyl-phenylalanine (FMP) and methionyl-leucyl-phenylalanine (FMLP) on gut permeability. A model of local inflammatory process.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't