Linked Life Data

2416403

Source:http://linkedlifedata.com/resource/pubmed/id/2416403

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1986-2-14
pubmed:abstractText
Exponential functions are commonly used to describe miniature endplate current (MEPC) decay; under control conditions a monoexponential is usually regarded as sufficient, whereas in the presence of some drugs a biexponential may be necessary. Using an automated fitting procedure which estimated exponential parameters and the period of decay from peak to baseline, a unimodal distribution of curvature was found for control MEPCs recorded in frog sartorius muscle. The majority of MEPCs were of monoexponential form, while the remainder were biexponential with either less or greater curvature than expected for a simple exponential (hypoexponential or hyperexponential, respectively). The proportion of MEPCs in each of the 3 groups was constant for a given endplate but varied between endplates. A possible explanation for this phenomenon could be differences in synaptic geometry within and between endplates. The increased curvature of individual MEPCs in the hyperexponential group was analyzed by assuming a sequential model for agonist blockade or desensitization, and calculating closing and reopening rate constants. These rate constants were altered by procaine and verapamil (100 microM) in a manner consistent with blockade of the acetylcholine receptor by enhancement of agonist-induced desensitization.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
23
pubmed:volume
360
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
224-34
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Distribution of exponentiality in miniature endplate current decay.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't