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rdf:type |
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lifeskim:mentions |
umls-concept:C0003842,
umls-concept:C0021516,
umls-concept:C0027893,
umls-concept:C0028351,
umls-concept:C0028977,
umls-concept:C0038585,
umls-concept:C0042395,
umls-concept:C0042449,
umls-concept:C0086418,
umls-concept:C0871261,
umls-concept:C1519957,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
1
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pubmed:dateCreated |
1986-1-14
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pubmed:abstractText |
Human omental arteries and veins are supplied with nerve fibers containing noradrenaline (NA) and neuropeptide Y (NPY); these two agents probably co-exist in perivascular sympathetic nerve fibers. Substance P (SP)- or vasoactive intestinal peptide (VIP)-containing fibers could not be detected. In studies on isolated omental vessels NA produced constriction. The results of blockade experiments suggest that human omental arteries are equipped predominantly with alpha 1-adrenoceptors and omental veins with a mixture of alpha 1- and alpha 2-adrenoceptors. NPY at a concentration of 10(-7) M or higher had a weak contractile effect on veins and virtually no effect on arteries. NPY at a concentration of 3 X 10(-8) M shifted the NA concentration response curve to the left in arteries (pD2 = 5.8 for NA versus 6.6. for NA in the presence of NPY; P less than 0.001) but not in veins. Both SP and VIP relaxed arteries precontracted with NA or prostaglandin F2 alpha (PGF2 alpha). The potency of SP as a relaxant agent was similar in arteries and veins; the effect of VIP was elicited at lower concentrations in veins than in arteries.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprost,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptide Y,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Prazosin,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandins F,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Substance P,
http://linkedlifedata.com/resource/pubmed/chemical/Vasoactive Intestinal Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Yohimbine
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0167-0115
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
67-79
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2416012-Aged,
pubmed-meshheading:2416012-Arteries,
pubmed-meshheading:2416012-Dinoprost,
pubmed-meshheading:2416012-Female,
pubmed-meshheading:2416012-Histocytochemistry,
pubmed-meshheading:2416012-Humans,
pubmed-meshheading:2416012-Male,
pubmed-meshheading:2416012-Middle Aged,
pubmed-meshheading:2416012-Muscle, Smooth, Vascular,
pubmed-meshheading:2416012-Muscle Contraction,
pubmed-meshheading:2416012-Nerve Tissue Proteins,
pubmed-meshheading:2416012-Neurons,
pubmed-meshheading:2416012-Neuropeptide Y,
pubmed-meshheading:2416012-Norepinephrine,
pubmed-meshheading:2416012-Omentum,
pubmed-meshheading:2416012-Prazosin,
pubmed-meshheading:2416012-Prostaglandins F,
pubmed-meshheading:2416012-Receptors, Adrenergic, alpha,
pubmed-meshheading:2416012-Regional Blood Flow,
pubmed-meshheading:2416012-Substance P,
pubmed-meshheading:2416012-Vasoactive Intestinal Peptide,
pubmed-meshheading:2416012-Vasomotor System,
pubmed-meshheading:2416012-Veins,
pubmed-meshheading:2416012-Yohimbine
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pubmed:year |
1985
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pubmed:articleTitle |
Innervation of human omental arteries and veins and vasomotor response to noradrenaline, neuropeptide Y, substance P and vasoactive intestinal peptide.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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