Linked Life Data

2413812

Source:http://linkedlifedata.com/resource/pubmed/id/2413812

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1985-11-18
pubmed:abstractText
The effects of vanadate (Na3VO4: VAN) on isolated tracheal smooth muscle of monkey (Macaca fascicularis) and rabbit were examined. VAN (10(-5)-10(-3) M) induced a sustained contraction in both tracheae which was not affected by atropine, tetrodotoxin or tripelennamine. Indomethacin potentiated VAN-induced contraction in monkey trachea but had no effect in rabbit trachea. In Ca-free solution, high K was ineffective whereas VAN or carbachol induced a small transient contraction. In both tracheae, the K-induced contraction was completely inhibited by verapamil while the VAN- and carbachol-induced contractions were partially inhibited by this inhibitor. Sodium nitroprusside was ineffective in rabbit trachea. In monkey trachea, however, K-induced contraction was completely inhibited and VAN- and carbachol-induced contractions were partially inhibited by sodium nitroprusside. Readmission of 5.4 mM K transiently relaxed the carbachol-induced contraction in trachea pretreated with a K-free solution. Ouabain completely and VAN partially inhibited this K-induced relaxation. VAN slightly increased the cellular Na content in rabbit trachea but not in monkey trachea. Previous inhibition of the Na pump activity by a K-free solution containing ouabain did not inhibit the VAN-induced contraction. It is concluded that VAN induces a transient, followed by a sustained contraction in both monkey and rabbit tracheae. The former contraction may be due to a release of cellular Ca and the latter to an influx of external Ca. VAN-induced contractions do not seem to be due to an inhibition of the Na pump activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0301-4533
pubmed:author
pubmed:issnType
Print
pubmed:volume
276
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
120-32
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Contractile effects of vanadate on monkey and rabbit tracheal smooth muscle.
pubmed:publicationType
Journal Article, In Vitro