Linked Life Data

2413617

Source:http://linkedlifedata.com/resource/pubmed/id/2413617

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1985-10-25
pubmed:abstractText
A sensitive microneutralization assay was used to detect antigenic variants of Coxsackievirus B4. Analysis of 47 clinical isolates with 16 monoclonal neutralizing antibodies revealed highly conserved, moderately conserved, and poorly conserved epitopes. Upon passage of Coxsackievirus B4 in tissue culture, certain epitopes disappeared and others appeared in the apparent absence of selective pressure. Changes in epitopes often exceeded a frequency of 10(-2). Despite considerable variation in individual epitopes, the overall antigenic composition of Coxsackievirus B4, as measured by the capacity of hyperimmune serum to neutralize clinical isolates, remains fairly constant.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0042-6822
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
146
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
302-6
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Detection of conserved and nonconserved epitopes on Coxsackievirus B4: frequency of antigenic change.
pubmed:publicationType
Journal Article