Linked Life Data

2413515

Source:http://linkedlifedata.com/resource/pubmed/id/2413515

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1985-11-8
pubmed:abstractText
1-Methylguanine and 7-methylguanine are naturally occurring modified purines derived from tRNA, found in elevated levels in the serum and urine of cancer patients. When C3H/10T1/2 clone-8 mouse cells are exposed to low levels of the methylated purines, they are induced to differentiate into adipocytes. Differentiation is induced in a dose-dependent manner and is similar in extent to that achieved by other inducing agents, such as 5-azacytidine. The methylated purines are not mutagenic, nor are they incorporated into DNA. They may exert their effect by modifying cellular regulatory processes, such as methylation of DNA. High levels of circulating methylated purines in cancer patients may play a role in tumor-host interactions.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1010-4283
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
115-21
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Induction of adipocyte formation in 10T1/2 cells by 1-methylguanine and 7-methylguanine.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.