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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1985-10-30
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pubmed:abstractText |
A murine pregnancy-associated protein (alpha 1-PAP) was demonstrated by immunoperoxidase (PAP) staining within Ia positive cells in gut-associated lymphoid tissue and intestinal mucosae of normal female MF1 but not C57BL/10 mice. These immunohistochemical findings reflect the differences in serum alpha 1-PAP concentrations between the two strains, being 50-fold higher in the MF1 females. Staining for alpha 1-PAP was also detected within perivascular and periportal hepatocytes of MF1 mice. Using a combined indirect immunoperoxidase (PAP)/direct immunofluorescence procedure, cytoplasmic alpha 1-PAP was demonstrated in a proportion of plasma cells secreting the IgA isotype. In contrast with human pregnancy-associated alpha 2-glycoprotein (alpha 2-PAG) which was observed in the majority of IgA plasma cells within the lamina propria of human gastrointestinal mucosae, on average only 15% of IgA producers in corresponding mouse tissue were positive for alpha 1-PAP. As with the localization of alpha 2-PAG, no other classes of Ig-producing cells stained for alpha 1-PAP. These observations strengthen recent proposals that alpha 1-PAP is a murine analogue of human alpha 2-PAG, a glycoprotein with immunosuppressive properties.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2412747-1116554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2412747-358751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2412747-370031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2412747-4159523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2412747-4162812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2412747-4168889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2412747-423976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2412747-46831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2412747-53482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2412747-6085894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2412747-6159336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2412747-6202814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2412747-6262965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2412747-6342887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2412747-6367595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2412747-6513499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2412747-6600258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2412747-6699817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2412747-6821474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2412747-6977028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2412747-7021602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2412747-7040559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2412747-7126157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2412747-722672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2412747-7429885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2412747-81516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2412747-855655
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
397-405
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2412747-Animals,
pubmed-meshheading:2412747-Cross Reactions,
pubmed-meshheading:2412747-Female,
pubmed-meshheading:2412747-Histocompatibility Antigens Class II,
pubmed-meshheading:2412747-Humans,
pubmed-meshheading:2412747-Immunoenzyme Techniques,
pubmed-meshheading:2412747-Immunoglobulin A,
pubmed-meshheading:2412747-Intestinal Mucosa,
pubmed-meshheading:2412747-Liver,
pubmed-meshheading:2412747-Mice,
pubmed-meshheading:2412747-Mice, Inbred C57BL,
pubmed-meshheading:2412747-Microscopy, Electron,
pubmed-meshheading:2412747-Plasma Cells,
pubmed-meshheading:2412747-Pregnancy Proteins,
pubmed-meshheading:2412747-Pregnancy-Associated Plasma Protein-A
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pubmed:year |
1985
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pubmed:articleTitle |
Immunohistochemical localization of murine alpha 1-pregnancy-associated protein (alpha 1-PAP) in non-pregnant females: a comparative study with human pregnancy-associated alpha 2-glycoprotein (alpha 2-PAG).
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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