Linked Life Data

2412191

Source:http://linkedlifedata.com/resource/pubmed/id/2412191

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1985-10-7
pubmed:abstractText
Intrathecal administration of both (D-Pro2,D-Trp7,9)-substance P (DPDT) and (D-Arg1,D-Trp7,9,Leu11)-substance P (DADTL) elicited antinociception in hot-plate and tail-flick test, with DADTL as the most potent. The animals injected with 2.0 micrograms DADTL, and several animals administered with DPDT at the same dose, developed bilateral motor blockade of the hind-legs, persisting for up to 3 days after DADTL. The effect of DPDT appeared to be reversible at this dose. On histopathological examination it was found that these animals with persistent paralysis had widespread neuronal necrosis in the lumbar region of the spinal cord. It is concluded that the peptides have antinociceptive effects after the intrathecal administration in rats, but that there is a small margin between the dose producing this effect and that causing irreversible toxic reactions in the spinal cord.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
12
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
159-64
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Antinociceptive and neurotoxic actions of substance P analogues in the rat's spinal cord after intrathecal administration.
pubmed:publicationType
Journal Article