Linked Life Data

2412026

Source:http://linkedlifedata.com/resource/pubmed/id/2412026

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1985-10-17
pubmed:abstractText
In the spontaneously hypertensive rat (SHR), ketanserin and the ketanserin analogues R56413 and ritanserin were studied with regard to their ability to reduce the blood pressure in conscious rats and shift the dose-response curves for phenylephrine and serotonin (5-HT) in pithed rats after acute administration. There was a striking correlation between the degree of hypotension and the degree of inhibition of the phenylephrine-induced pressor responses. 5-HT2-receptor blockade alone by ritanserin did not influence the blood pressure but it potentiated the hypotensive response to alpha 1-adrenoceptor blockade by prazosin. Thus, following acute administration in the SHR, the major portion of the antihypertensive response to ketanserin is due to an alpha 1-adrenoceptor blockade but the 5-HT2-receptor blockade may contribute.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0160-2446
pubmed:author
pubmed:issnType
Print
pubmed:volume
7 Suppl 7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S110-1
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Antihypertensive effects of ketanserin in the spontaneously hypertensive rat: mode of action.
pubmed:publicationType
Journal Article