Linked Life Data

2411613

Source:http://linkedlifedata.com/resource/pubmed/id/2411613

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pubmed-article:2411613pubmed:abstractTextWe examined aspects of the mechanism of desensitization of adenylate cyclase activation by TSH in a cloned line of rat thyroid cells (FRTL). Increasing FRTL intracellular cAMP concentrations by preincubation for 6 h in either 1 mM dBcAMP or 100 microM forskolin did not induce TSH desensitization. Forskolin stimulation was unimpaired in TSH-desensitized cells, indicating 'uncoupling' of the adenylate cyclase catalytic unit from the TSH receptor. Stimulation by the Ni inhibitory pathway of the adenylate cyclase by epinephrine (10(-6) M-10(-4) M in the presence of 10(-4) M propranolol) was unaltered in cells previously desensitized to TSH. That is, Ni-mediated inhibition of adenylate cyclase was additive to TSH desensitization. Pre-exposure of FRTL cells for 18 h to 50 ng/ml pertussis toxin did not prevent the induction of TSH desensitization. TSH desensitization was prevented by cycloheximide or actinomycin D added during the last 3-4 h of a 6 h period of TSH stimulation. The rates of turnover of the putative desensitization protein and its mRNA therefore appear to be similar.lld:pubmed
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pubmed-article:2411613pubmed:articleTitleStudies on the mechanism of desensitization of the cyclic AMP response to TSH stimulation in a cloned rat thyroid cell line.lld:pubmed
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pubmed-article:2411613pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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