Linked Life Data

2411574

Source:http://linkedlifedata.com/resource/pubmed/id/2411574

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1985-10-9
pubmed:abstractText
The effects of the negative inotropic agent, diacetyl monoxime (DAM), were studied on cardiac action potentials in young (3 day old) and old (13-18 day old) embryonic chick hearts and in rabbit papillary muscles. DAM (5-10 mM) decreased the action potential (AP) amplitude, the maximum rate of rise (Vmax), and AP duration of slow and fast APs in both young and old embryonic chick hearts. Concomitantly with these changes, the spontaneous beating rate was increased in young hearts. At 20 mM DAM, the maximum diastolic potential (MDP) was decreased. In fast APs of old embryonic chick hearts, the most prominent effect of DAM was a shortening of AP duration, the effects on AP amplitude, Vmax, and resting potential being less. In rabbit papillary muscles, DAM had little effect on the slow AP parameters except for shortening of AP duration. The onset of the DAM effects was rapid, the peak effect being attained by 5 min in all preparations. Reversal of the effects of DAM upon washout were fast, complete recovery being attained within 10 min. We conclude that DAM suppressed the slow Na+ current present in young chick embryonic hearts. The effects of DAM, up to 10 mM, on Vmax of the fast Na+-dependent APs in old embryonic chick hearts was less, and there was no effect on rabbit hearts. DAM suppressed the slow Ca2+-dependent APs in old embryonic chick hearts but not in rabbit papillary muscles, suggesting that the effect of DAM on the Ca2+ slow channels depends on the species.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
7
pubmed:volume
112
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
145-52
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Effects of diacetyl monoxime (DAM) on slow and fast action potentials of young and old embryonic chick hearts and rabbit hearts.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.