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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2 Pt 1
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pubmed:dateCreated |
1985-9-11
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pubmed:abstractText |
Basal and maximally insulin-stimulated Na+-pump activity was measured in adipocytes from subjects with normal glucose tolerance over a range of body mass indexes (BMI). In a comparison of 13 lean (BMI less than 25) vs. 15 extremely obese (BMI greater than 40) subjects basal activities per unit surface area were similar, but the maximally insulin-stimulated activity was significantly reduced in the extremely obese group [9.2 +/- 0.6 vs. 12.1 +/- 1.0 (min X dam2)-1, P less than 0.05]. The mean percent insulin stimulation of the Na+ pump above basal activity was 48 +/- 7% for the lean compared with 14 +/- 2% for the extremely obese group (P less than 0.001). A similar relationship was observed in these subjects for glucose transport where basal activities per unit surface area again were similar but the maximally insulin-stimulated transport was reduced in the extremely obese subjects (2.2 +/- 0.3 vs 5.1 +/- 0.6 attol/um2 X s, P less than 0.001). These results indicate that alterations in Na+-pump activity may be a manifestation of the insulin-resistant state that could contribute to the development of obesity via decreased cellular thermogenesis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Ion Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Ouabain,
http://linkedlifedata.com/resource/pubmed/chemical/Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Rubidium,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0002-9513
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
249
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
E160-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2411146-Adipose Tissue,
pubmed-meshheading:2411146-Adolescent,
pubmed-meshheading:2411146-Adult,
pubmed-meshheading:2411146-European Continental Ancestry Group,
pubmed-meshheading:2411146-Female,
pubmed-meshheading:2411146-Glucose,
pubmed-meshheading:2411146-Humans,
pubmed-meshheading:2411146-Indians, North American,
pubmed-meshheading:2411146-Insulin Resistance,
pubmed-meshheading:2411146-Ion Channels,
pubmed-meshheading:2411146-Male,
pubmed-meshheading:2411146-Middle Aged,
pubmed-meshheading:2411146-Obesity,
pubmed-meshheading:2411146-Ouabain,
pubmed-meshheading:2411146-Radioisotopes,
pubmed-meshheading:2411146-Rubidium,
pubmed-meshheading:2411146-Sodium
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pubmed:year |
1985
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pubmed:articleTitle |
Insulin-resistant Na+ pump activity in adipocytes from obese humans.
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pubmed:publicationType |
Journal Article,
In Vitro
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