|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
1985-9-9
|
|
pubmed:abstractText |
Thirty-eight patients with extragonadal germ-cell tumors treated at Memorial Sloan-Kettering Cancer Center (New York) between 1975 and 1982 received high-dose cisplatin-based chemotherapy. Complete response was achieved in 89% of patients with pure seminoma and all complete responders are alive without evidence of disease (median follow-up time, 29+ months). Complete response was achieved in only 41% (12 of 29) of patients with extragonadal nonseminomatous germ-cell tumors; only four patients are alive and free of disease (median survival time, 18 months). Although patients with extragonadal seminoma respond well with current cisplatin-based chemotherapy, minimal improvement in CR rates has been achieved in patients with extragonadal nonseminomatous tumors. Patients with extragonadal nonseminomatous germ-cell tumors have a relatively poor prognosis when compared to patients with primary testicular tumors and investigational trials of innovative therapy should be considered.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0732-183X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
3
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1073-8
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:2410574-Adolescent,
pubmed-meshheading:2410574-Adult,
pubmed-meshheading:2410574-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:2410574-Bleomycin,
pubmed-meshheading:2410574-Chlorambucil,
pubmed-meshheading:2410574-Cisplatin,
pubmed-meshheading:2410574-Cyclophosphamide,
pubmed-meshheading:2410574-Dactinomycin,
pubmed-meshheading:2410574-Doxorubicin,
pubmed-meshheading:2410574-Dysgerminoma,
pubmed-meshheading:2410574-Female,
pubmed-meshheading:2410574-Humans,
pubmed-meshheading:2410574-Male,
pubmed-meshheading:2410574-Middle Aged,
pubmed-meshheading:2410574-Neoplasm Recurrence, Local,
pubmed-meshheading:2410574-Neoplasms, Germ Cell and Embryonal,
pubmed-meshheading:2410574-Prognosis,
pubmed-meshheading:2410574-Vinblastine
|
|
pubmed:year |
1985
|
|
pubmed:articleTitle |
The results of chemotherapy for extragonadal germ-cell tumors in the cisplatin era: the Memorial Sloan-Kettering Cancer Center experience (1975 to 1982).
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
