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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1985-8-30
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pubmed:abstractText |
The involvement of lysosomes in the normal secretory process of the exocrine pancreas and in the onset of acute, hormone-induced pancreatitis was studied. The enzymatic activities of cathepsin B and beta-galactosidase were determined in the pancreas of rats that had been stimulated by either maximal (0.25 microgram X kg-1 h-1) or supramaximal (5 micrograms X kg-1 h-1) concentrations of cerulein. Maximal stimulation led to a moderate increase in cathepsin B activity and the ultrastructural appearance of multivesicular bodies. Supramaximal stimulation resulted in formation of large cytoplasmic vacuoles and progressive destruction of acinar cells which was paralleled by a marked increase of lysosomal enzyme activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0012-2823
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
10-8
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:2410315-Amylases,
pubmed-meshheading:2410315-Animals,
pubmed-meshheading:2410315-Autophagy,
pubmed-meshheading:2410315-Caerulein,
pubmed-meshheading:2410315-Cathepsin B,
pubmed-meshheading:2410315-Cathepsins,
pubmed-meshheading:2410315-Hydrolysis,
pubmed-meshheading:2410315-Lysosomes,
pubmed-meshheading:2410315-Male,
pubmed-meshheading:2410315-Pancreatitis,
pubmed-meshheading:2410315-Phagocytosis,
pubmed-meshheading:2410315-Rats,
pubmed-meshheading:2410315-Rats, Inbred Strains,
pubmed-meshheading:2410315-beta-Galactosidase
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pubmed:year |
1985
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pubmed:articleTitle |
Cerulein-induced pancreatitis in rats: increased lysosomal enzyme activity and autophagocytosis.
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pubmed:publicationType |
Journal Article
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