Linked Life Data

2409637

Source:http://linkedlifedata.com/resource/pubmed/id/2409637

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1985-7-29
pubmed:abstractText
To investigate the effects of the estrogenic insecticide chlordecone on the morphology of mouse choroid plexus, 4 different doses (100.0, 250.0, 500.0 and 1000.0 micrograms) of the chemical were administered intraperitoneally to groups of adult males. Concurrent with the chlordecone treatments, another group of males received 10.0 micrograms estradiol-17 beta; the control group was treated with sesame oil vehicle. After 15 days of daily chemical injections, the mice were terminated and the choroid plexus from fourth ventricle examined morphologically. Scanning (SEM) and transmission (TEM) electron microscopic examination of control choroid plexus showed the cuboidal epithelium profusely covered with microvilli. SEM examinations of choroid plexus epithelium after chlordecone treatments revealed dose-dependent, cell alterations that effected the microvilli and cell surfaces. After the highest chlordecone dose, microvilli were no longer visible, the choroidal cell membrane appeared either smooth or pitted and there was evidence of increased luminal debris. TEM observations of the same choroid plexus cells revealed vacuolated cytoplasm, dilated endoplasmic reticulum, vacuolated mitochondria with disrupted cristae and cellular degeneration. SEM and TEM examination of choroid plexus after estradiol treatments revealed similar cellular alterations to those recorded after chlordecone treatments. The possible significance of these data are discussed.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0300-483X
pubmed:author
pubmed:issnType
Print
pubmed:day
14
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
219-30
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Transmission and scanning electron microscopic study of chlordecone (Kepone) induced changes in the male mouse choroid plexus.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't