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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4712
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pubmed:dateCreated |
1985-8-22
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pubmed:abstractText |
Crude fractions of urine from pregnant women are immunosuppressive in vitro. An 85-kilodalton immunosuppressive glycoprotein purified to homogeneity from such urine inhibited in vitro assays of human T-cell and monocyte activity at concentrations of 10(-9) to 10(-11) molar. This material was nontoxic and blocked early events required for normal T-cell proliferation in vitro. On the basis of its tissue source and its in vitro activity, the name "uromodulin" is proposed for this glycoprotein.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
229
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
479-81
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:2409603-B-Lymphocytes,
pubmed-meshheading:2409603-Chromatography,
pubmed-meshheading:2409603-Collodion,
pubmed-meshheading:2409603-Cytotoxicity, Immunologic,
pubmed-meshheading:2409603-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:2409603-Epitopes,
pubmed-meshheading:2409603-Female,
pubmed-meshheading:2409603-Hemolytic Plaque Technique,
pubmed-meshheading:2409603-Humans,
pubmed-meshheading:2409603-Immunosuppressive Agents,
pubmed-meshheading:2409603-Isoelectric Focusing,
pubmed-meshheading:2409603-Lymphocyte Activation,
pubmed-meshheading:2409603-Molecular Weight,
pubmed-meshheading:2409603-Mucoproteins,
pubmed-meshheading:2409603-Pregnancy,
pubmed-meshheading:2409603-Pregnancy Proteins,
pubmed-meshheading:2409603-T-Lymphocytes,
pubmed-meshheading:2409603-Uromodulin
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pubmed:year |
1985
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pubmed:articleTitle |
Uromodulin: a unique 85-kilodalton immunosuppressive glycoprotein isolated from urine of pregnant women.
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pubmed:publicationType |
Journal Article,
In Vitro
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