Linked Life Data

2409166

Source:http://linkedlifedata.com/resource/pubmed/id/2409166

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2 Suppl
pubmed:dateCreated
1985-8-22
pubmed:abstractText
Neuropeptides present in the peripheral nervous system (PNS) and central nervous system (CNS) modify diverse functions of human, murine and guinea pig mononuclear leukocytes in vitro and in vivo by receptor-mediated mechanisms. Both stimulatory and inhibitory effects on lymphocytes and macrophages have been demonstrated for different neuropeptides in vitro at concentrations which are similar to those in the circulation and in tissues. The dissociation constant (KD) for the binding of a neuropeptide to its lymphocyte receptor is within the range of concentrations that evoke lymphocyte responses critical to immunity and hypersensitivity. The receptor-mediated interactions of diverse neuropeptides with immunocompetent cells provide one mechanism through which the PNS may influence localized immune responses and the CNS may alter systemic immunity.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:volume
135
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
783s-786s
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Modulation of lymphocyte function by sensory neuropeptides.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't