|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
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pubmed:dateCreated |
1985-8-6
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|
pubmed:abstractText |
The phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (IBMX) mimicked the effects of isoprenaline on the force of contraction, the cAMP content and the slow Ca++ inward current (Isi) in isolated guinea pig papillary muscles. The results support the hypothesis that phosphodiesterase inhibitors and beta-adrenoceptor agonists exert their positive inotropic effects by increasing Isi via the common mediator cAMP.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Jun
|
|
pubmed:issn |
0014-4754
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:day |
15
|
|
pubmed:volume |
41
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
732-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2408914-1-Methyl-3-isobutylxanthine,
pubmed-meshheading:2408914-Action Potentials,
pubmed-meshheading:2408914-Animals,
pubmed-meshheading:2408914-Calcium,
pubmed-meshheading:2408914-Cyclic AMP,
pubmed-meshheading:2408914-Cyclic GMP,
pubmed-meshheading:2408914-Guinea Pigs,
pubmed-meshheading:2408914-Heart,
pubmed-meshheading:2408914-Ion Channels,
pubmed-meshheading:2408914-Isoproterenol,
pubmed-meshheading:2408914-Myocardial Contraction,
pubmed-meshheading:2408914-Stimulation, Chemical,
pubmed-meshheading:2408914-Theophylline
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|
pubmed:year |
1985
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|
pubmed:articleTitle |
Isoprenaline-like effects of the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine on mechanical, biochemical and electrophysiological parameters in the mammalian heart.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
