Linked Life Data

2408903

Source:http://linkedlifedata.com/resource/pubmed/id/2408903

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1985-8-19
pubmed:abstractText
The interleukin 2 receptor (IL2R) expression of a terpolymer of L-Glu60, L-Ala30, L-Tyr10 (GAT)-specific T helper (Th) cell line, L14, was studied using two different rat monoclonal antibodies specific for the murine IL2R, 7D4 and 5A2-2. L14 T cells expressed IL2R transiently, but contrary to the general assumption that IL2R expression is maintained only by periodic antigen stimulation, we observed that IL2 itself was able to regulate the level of IL2R on L14 Th lymphocytes. In particular, it was found that L14 T cells, which had not been recently stimulated and which expressed a very low level of high affinity IL2R, could be induced to exhibit a high level of this receptor after exposure to recombinant IL2, in the absence of any specific signal. In contrast, the Th cell line 52.3 used as control could be induced to express high levels of IL2R only after exposure to GAT; nevertheless, IL2 seems to play a critical role in the in vitro survival of the resting state of 52.3 T cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0014-2980
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
723-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Regulation of interleukin 2 (IL2) receptor expression: IL2 as an inducing signal for the expression of its own receptor on a murine T helper cell line.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't