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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4946
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pubmed:dateCreated |
1990-4-4
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pubmed:databankReference |
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pubmed:abstractText |
Cold-sensitive mutations in the SPB genes (spb1-spb7) of Saccharomyces cerevisiae suppress the inhibition of translation initiation resulting from deletion of the poly(A)-binding protein gene (PAB1). The SPB4 protein belongs to a family of adenosine triphosphate (ATP)-dependent RNA helicases. The aberrant production of 25S ribosomal RNA (rRNA) occurring in spb4-1 mutants or the deletion of SPB2 (RPL46) permits the deletion of PAB1. These data suggest that mutations affecting different steps of 60S subunit formation can allow PAB-independent translation, and they indicate that further characterization of the spb mutations could lend insight into the biogenesis of the ribosome.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
247
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1077-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:2408148-Amino Acid Sequence,
pubmed-meshheading:2408148-Base Sequence,
pubmed-meshheading:2408148-Carrier Proteins,
pubmed-meshheading:2408148-DEAD-box RNA Helicases,
pubmed-meshheading:2408148-Molecular Sequence Data,
pubmed-meshheading:2408148-Mutation,
pubmed-meshheading:2408148-Poly(A)-Binding Proteins,
pubmed-meshheading:2408148-Protein Biosynthesis,
pubmed-meshheading:2408148-RNA, Fungal,
pubmed-meshheading:2408148-RNA, Ribosomal,
pubmed-meshheading:2408148-RNA Nucleotidyltransferases,
pubmed-meshheading:2408148-RNA Processing, Post-Transcriptional,
pubmed-meshheading:2408148-Ribosomal Proteins,
pubmed-meshheading:2408148-Ribosomes,
pubmed-meshheading:2408148-Saccharomyces cerevisiae,
pubmed-meshheading:2408148-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:2408148-Sequence Homology, Nucleic Acid
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pubmed:year |
1990
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pubmed:articleTitle |
Translation initiation and ribosomal biogenesis: involvement of a putative rRNA helicase and RPL46.
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pubmed:affiliation |
Department of Biochemistry, Stanford Medical Center, CA 94305.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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