Linked Life Data

2406644

Source:http://linkedlifedata.com/resource/pubmed/id/2406644

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1990-3-19
pubmed:abstractText
Plasma and pineal 5-methoxytryptophol (ML) levels were determined by radioimmunoassay (RIA) following subcutaneous (s.c.) injection of ML (1, 25 and 100 micrograms) to hamsters, Mesocricetus auratus. A dose-dependent increase in plasma ML occurred, with the duration of the supra-physiological levels being related to the dose. However, only the 100 micrograms dose significantly increased pineal ML levels above control values. Plasma profiles after 1 or 25 micrograms ML fitted a one-compartment model with half-lives of 18.6 and 25.2 min, respectively. Following 100 micrograms ML a biphasic decay curve was evident, the half-lives of the 2 phases being 6.6 min and 2.95 h.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
108
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
138-42
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
5-Methoxytryptophol injections in the Syrian hamster: plasma and pineal concentrations.
pubmed:affiliation
Department of Biochemistry, University of Surrey, Guildford, U.K.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't