| pubmed-article:2406558 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2406558 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:2406558 | lifeskim:mentions | umls-concept:C0035679 | lld:lifeskim |
| pubmed-article:2406558 | lifeskim:mentions | umls-concept:C0596988 | lld:lifeskim |
| pubmed-article:2406558 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:2406558 | lifeskim:mentions | umls-concept:C1515021 | lld:lifeskim |
| pubmed-article:2406558 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2406558 | pubmed:dateCreated | 1990-3-26 | lld:pubmed |
| pubmed-article:2406558 | pubmed:abstractText | Saccharomyces cerevisiae RNA polymerase II conditional mutants that selectively disrupt the synthesis of specific mRNAs were isolated. At the permissive temperature, several of the mutants were inositol auxotrophs as a result of inadequate induction of INO1 transcription. The transcriptional defects exhibited by one of these Ino- mutants (rpb2-2) were further investigated. The induction of GAL10 and HIS4 transcription in rpb2-2 strains was similar to that of wild-type strains, in contrast to the lack of induction of INO1 transcription. When shifted to the nonpermissive temperature, cells containing rpb2-2 continued to accumulate some mRNAs but not others. Together, these results indicate that transcription of specific genes can be disrupted by RNA polymerase II mutations. The rpb2-2 allele alters an amino acid residue that occurs in a highly conserved segment of the RPB2 protein and that is shared by homologous subunits in other species. | lld:pubmed |
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| pubmed-article:2406558 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2406558 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2406558 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2406558 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:2406558 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:2406558 | pubmed:author | pubmed-author:YoungR ARA | lld:pubmed |
| pubmed-article:2406558 | pubmed:author | pubmed-author:NonetMM | lld:pubmed |
| pubmed-article:2406558 | pubmed:author | pubmed-author:ScaffBB | lld:pubmed |
| pubmed-article:2406558 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2406558 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:2406558 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2406558 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2406558 | pubmed:pagination | 1010-6 | lld:pubmed |
| pubmed-article:2406558 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2406558 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2406558 | pubmed:articleTitle | RNA polymerase II mutants defective in transcription of a subset of genes. | lld:pubmed |
| pubmed-article:2406558 | pubmed:affiliation | Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142. | lld:pubmed |
| pubmed-article:2406558 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2406558 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2406558 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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