|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1990-3-5
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|
pubmed:abstractText |
A novel route to activated phenolic sulfoxide analogs of sparsomycin has been developed. These analogs display an enhanced "preincubation effect" as inhibitors of peptide-bond formation. This time-dependent component of inhibition, which is postulated to result from an enzyme-mediated Pummerer rearrangement, is the dominant route to inhibition in these activated analogs.
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|
pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0006-291X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
30
|
|
pubmed:volume |
166
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
673-80
|
|
pubmed:dateRevised |
2006-11-15
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|
pubmed:meshHeading |
pubmed-meshheading:2405852-Acyltransferases,
pubmed-meshheading:2405852-Antibiotics, Antineoplastic,
pubmed-meshheading:2405852-Computer Graphics,
pubmed-meshheading:2405852-Escherichia coli,
pubmed-meshheading:2405852-Models, Molecular,
pubmed-meshheading:2405852-Peptide Chain Elongation, Translational,
pubmed-meshheading:2405852-Peptidyl Transferases,
pubmed-meshheading:2405852-Puromycin,
pubmed-meshheading:2405852-Ribosomes,
pubmed-meshheading:2405852-Sparsomycin,
pubmed-meshheading:2405852-Stereoisomerism,
pubmed-meshheading:2405852-Structure-Activity Relationship
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|
pubmed:year |
1990
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|
pubmed:articleTitle |
The chiral synthesis and biochemical properties of electron rich phenolic sulfoxide analogs of sparsomycin.
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|
pubmed:affiliation |
Merrell Dow Research Institute, Cincinnati, Ohio 45215.
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|
pubmed:publicationType |
Journal Article,
In Vitro
|
