|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0027869,
umls-concept:C0030685,
umls-concept:C0034650,
umls-concept:C0039696,
umls-concept:C0205359,
umls-concept:C0391871,
umls-concept:C0680255,
umls-concept:C1280500,
umls-concept:C1283071,
umls-concept:C1707723,
umls-concept:C1963578
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1975-12-11
|
|
pubmed:abstractText |
1 The effects of tetraphenylboron (TPB) on spontaneous transmitter release were studied in the frog sartorius muscle preparation. 2 TPB (0.001-1 mM) produced a time-dependent increase in miniature endplate potential (m.e.p.p.) activity that was not sustained. TPB (0.1 mM) produced similar effects on m.e.p.p. frequency in normal Ringer solutions, in the absence of Ca2+ or Cl- and in the presence of excess Ca2+ and of tetrodotoxin. The effect of TPB (0.01 mM) was reduced but not abolished in the absence of Ca2+. 3 As m.e.p.p. frequency fell from its peak level in TPB (0.04 mM) m.e.p.p. amplitude was reduced. The reduction of m.e.p.p. amplitude was not prevented by choline (30-300 muM). 4 When m.e.p.p. activity fell below the noise level in the presence of TPB (0.1 mM), lanthanum (0.5 mM) was ineffective in promoting measurable m.e.p.p. activity. 5 The effects of TPB were slowly reversible by washing. 6 The results indicate that TPB acts to reduce the nerve terminal stores of acetylcholine, probably by a combination of rapid release and concomitant inhibition of transmitter storage.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/240472-14321493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/240472-169931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/240472-4229179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/240472-4300871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/240472-4312878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/240472-4312879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/240472-4348350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/240472-4357869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/240472-4371582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/240472-4400110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/240472-4407352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/240472-4440560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/240472-4536612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/240472-4537254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/240472-4829228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/240472-5503879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/240472-5545181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/240472-5686268
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0007-1188
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
54
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
333-8
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:240472-Action Potentials,
pubmed-meshheading:240472-Animals,
pubmed-meshheading:240472-Anura,
pubmed-meshheading:240472-Boron Compounds,
pubmed-meshheading:240472-Calcium,
pubmed-meshheading:240472-Choline,
pubmed-meshheading:240472-Motor Endplate,
pubmed-meshheading:240472-Neuromuscular Junction,
pubmed-meshheading:240472-Neurotransmitter Agents,
pubmed-meshheading:240472-Potassium,
pubmed-meshheading:240472-Synaptic Transmission,
pubmed-meshheading:240472-Tetraphenylborate,
pubmed-meshheading:240472-Time Factors
|
|
pubmed:year |
1975
|
|
pubmed:articleTitle |
The effects of tetraphenylboron on spontaneous transmitter release at the frog neuromuscular junction.
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
|
