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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1990-3-15
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pubmed:abstractText |
1. The rate and extent of felodipine absorption from an oral solution, conventional and extended-release tablets were investigated in two groups of healthy volunteers (n = 18 + 15). 2. The antihypertensive effect of felodipine conventional tablets twice daily (n = 71) and extended-release tablets once daily (n = 76) were compared in a parallel-group study in hypertensive patients. 3. As from a solution, felodipine was completely absorbed from the two solid dosage forms. The rate of absorption increased in the order extended-release tablets, conventional tablets, solution. 4. The extended-release tablet gave more sustained plasma concentrations than the conventional tablet. 5. The extended-release tablet given once daily gave similar blood pressure control to the conventional tablet given twice daily.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0306-5251
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
39-45
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2404502-Adult,
pubmed-meshheading:2404502-Biological Availability,
pubmed-meshheading:2404502-Blood Pressure,
pubmed-meshheading:2404502-Delayed-Action Preparations,
pubmed-meshheading:2404502-Double-Blind Method,
pubmed-meshheading:2404502-Felodipine,
pubmed-meshheading:2404502-Heart Rate,
pubmed-meshheading:2404502-Hemodynamics,
pubmed-meshheading:2404502-Humans,
pubmed-meshheading:2404502-Hypertension,
pubmed-meshheading:2404502-Male,
pubmed-meshheading:2404502-Randomized Controlled Trials as Topic,
pubmed-meshheading:2404502-Solubility,
pubmed-meshheading:2404502-Tablets
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pubmed:year |
1990
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pubmed:articleTitle |
Plasma concentration profiles and antihypertensive effect of conventional and extended-release felodipine tablets.
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pubmed:affiliation |
Cardiovascular research, AB Hässle, Mölndal, Sweden.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial
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