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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4940
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pubmed:dateCreated |
1990-2-20
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pubmed:databankReference |
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pubmed:abstractText |
Interleukin-3 (IL-3) binds to its receptor with high and low affinities, induces tyrosine phosphorylation, and promotes the proliferation and differentiation of hematopoietic cells. A binding component of the IL-3 receptor was cloned. Fibroblasts transfected with the complementary DNA bound IL-3 with a low affinity [dissociation constant (Kd) of 17.9 +/- 3.6 nM]. No consensus sequence for a tyrosine kinase was present in the cytoplasmic domain. Thus, additional components are required for a functional high affinity IL-3 receptor. A sequence comparison of the IL-3 receptor with other cytokine receptors (erythropoietin, IL-4, IL-6, and the beta chain IL-2 receptor) revealed a common motif of a distinct receptor gene family.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
247
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
324-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:2404337-Amino Acid Sequence,
pubmed-meshheading:2404337-Animals,
pubmed-meshheading:2404337-Cloning, Molecular,
pubmed-meshheading:2404337-DNA,
pubmed-meshheading:2404337-DNA Probes,
pubmed-meshheading:2404337-Escherichia coli,
pubmed-meshheading:2404337-Fibroblasts,
pubmed-meshheading:2404337-Interleukin-3,
pubmed-meshheading:2404337-Mice,
pubmed-meshheading:2404337-Molecular Sequence Data,
pubmed-meshheading:2404337-Nucleic Acid Hybridization,
pubmed-meshheading:2404337-Plasmids,
pubmed-meshheading:2404337-Protein-Tyrosine Kinases,
pubmed-meshheading:2404337-Receptors, Immunologic,
pubmed-meshheading:2404337-Receptors, Interleukin-3,
pubmed-meshheading:2404337-Sequence Homology, Nucleic Acid,
pubmed-meshheading:2404337-Transfection
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pubmed:year |
1990
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pubmed:articleTitle |
Cloning of an interleukin-3 receptor gene: a member of a distinct receptor gene family.
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pubmed:affiliation |
Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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