Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1990-2-9
pubmed:abstractText
Despite their rarity and physiologically neutral character, more inherited structural variants of serum albumin (alloalbumins) are known than for any other human protein except hemoglobin. Including three previously unreported examples described here, we have identified 13 different point substitutions in alloalbumins of Japanese origin. Of these only albumin B and two proalbumins have been reported in other ethnic groups, and these are the most common variants of European origin. Some alloalbumins of Asiatic origin, but not yet identified in Japanese, are present in diverse ethnic groups. An alloalbumin found in indigenes of New Guinea (lysine----asparagine at position 313) is also present in Caucasians of various European descents. Albumin Lambadi, occurring in a tribal group in south India, has a mutation (glutamic acid----lysine at position 501) also found as a rare variant in individuals of diverse ethnic origin resident on four continents. These results suggest that some alloalbumins with the same substitution may have originated by independent mutations in various populations. This, together with the apparent clustering of point substitutions in the protein structure, may reflect hypermutability of the albumin gene.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2404284-2104980, http://linkedlifedata.com/resource/pubmed/commentcorrection/2404284-2564675, http://linkedlifedata.com/resource/pubmed/commentcorrection/2404284-2727704, http://linkedlifedata.com/resource/pubmed/commentcorrection/2404284-2762316, http://linkedlifedata.com/resource/pubmed/commentcorrection/2404284-2901102, http://linkedlifedata.com/resource/pubmed/commentcorrection/2404284-2911589, http://linkedlifedata.com/resource/pubmed/commentcorrection/2404284-2914956, http://linkedlifedata.com/resource/pubmed/commentcorrection/2404284-3009475, http://linkedlifedata.com/resource/pubmed/commentcorrection/2404284-3081519, http://linkedlifedata.com/resource/pubmed/commentcorrection/2404284-3238276, http://linkedlifedata.com/resource/pubmed/commentcorrection/2404284-3338164, http://linkedlifedata.com/resource/pubmed/commentcorrection/2404284-3474609, http://linkedlifedata.com/resource/pubmed/commentcorrection/2404284-3478700, http://linkedlifedata.com/resource/pubmed/commentcorrection/2404284-3479777, http://linkedlifedata.com/resource/pubmed/commentcorrection/2404284-3689800, http://linkedlifedata.com/resource/pubmed/commentcorrection/2404284-3733924, http://linkedlifedata.com/resource/pubmed/commentcorrection/2404284-3828358, http://linkedlifedata.com/resource/pubmed/commentcorrection/2404284-3972422, http://linkedlifedata.com/resource/pubmed/commentcorrection/2404284-4027254, http://linkedlifedata.com/resource/pubmed/commentcorrection/2404284-4758279, http://linkedlifedata.com/resource/pubmed/commentcorrection/2404284-4768559, http://linkedlifedata.com/resource/pubmed/commentcorrection/2404284-5119765, http://linkedlifedata.com/resource/pubmed/commentcorrection/2404284-6994450, http://linkedlifedata.com/resource/pubmed/commentcorrection/2404284-7216224, http://linkedlifedata.com/resource/pubmed/commentcorrection/2404284-7353034
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
87
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
497-501
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Point substitutions in albumin genetic variants from Asia.
pubmed:affiliation
Department of Biology, Indiana University, Bloomington 47405.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.