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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1990-2-22
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pubmed:abstractText |
Thirty-one patients with advanced malignant mesothelioma, previously untreated or having received only one prior cytotoxic regimen, were treated in a prospective, single-arm phase II trial with carboplatin (NSC 241240) at a dose of 150 mg/m2 per day intravenously (IV) for 3 days (450 mg/m2/course). One complete remission and four partial remissions were achieved, yielding an overall objective response rate of 16% (95% confidence interval [CI], 5.4% to 34%). The median duration of remission was 8 months (range, 5 to 17). Nonhematological toxicity was mild (only 12% with World Health Organization [WHO] grade 3 vomiting); 16% suffered WHO grade 3 to 4 hematological toxicity, but there were no life-threatening episodes and no treatment-related deaths. Carboplatin has modest activity against malignant mesothelioma and, because of its low toxicity, has a role in the management of this disease.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0732-183X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
151-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2404086-Adolescent,
pubmed-meshheading:2404086-Adult,
pubmed-meshheading:2404086-Aged,
pubmed-meshheading:2404086-Carboplatin,
pubmed-meshheading:2404086-Drug Evaluation,
pubmed-meshheading:2404086-Drug Tolerance,
pubmed-meshheading:2404086-Humans,
pubmed-meshheading:2404086-Infusions, Intravenous,
pubmed-meshheading:2404086-Mesothelioma,
pubmed-meshheading:2404086-Middle Aged,
pubmed-meshheading:2404086-Organoplatinum Compounds,
pubmed-meshheading:2404086-Remission Induction,
pubmed-meshheading:2404086-Time Factors
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pubmed:year |
1990
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pubmed:articleTitle |
Phase II trial of carboplatin in the management of malignant mesothelioma.
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pubmed:affiliation |
Department of Clinical Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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