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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1990-2-1
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pubmed:abstractText |
The transcription start site and promoter of the rat gene coding for the transcription factor NF-1 have been identified. The NF-1 promoter was fused to the chloramphenicol acetyltransferase-coding sequence, and the resulting plasmid was transcriptionally active in the HepG2 cell line. Footprinting and gel retardation analysis indicated that the transcription factor Sp1 binds to the NF-1 promoter. Mutants in the Sp1-binding site displayed a strong reduction in transcriptional activity.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2403642-2460858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2403642-2563673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2403642-2787245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2403642-2824193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2403642-2844524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2403642-2884726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2403642-2895896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2403642-2904653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2403642-3017657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2403642-3034601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2403642-3046753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2403642-3050531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2403642-3053160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2403642-3262058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2403642-3334721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2403642-3398920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2403642-3461465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2403642-3475566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2403642-3821727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2403642-6294651
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
387-90
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2403642-Animals,
pubmed-meshheading:2403642-Base Sequence,
pubmed-meshheading:2403642-Binding Sites,
pubmed-meshheading:2403642-Cell Line,
pubmed-meshheading:2403642-DNA-Binding Proteins,
pubmed-meshheading:2403642-Humans,
pubmed-meshheading:2403642-Molecular Sequence Data,
pubmed-meshheading:2403642-Nuclear Proteins,
pubmed-meshheading:2403642-Promoter Regions, Genetic,
pubmed-meshheading:2403642-Rats,
pubmed-meshheading:2403642-Restriction Mapping,
pubmed-meshheading:2403642-Sp1 Transcription Factor,
pubmed-meshheading:2403642-Transcription, Genetic,
pubmed-meshheading:2403642-Transcription Factors
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pubmed:year |
1990
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pubmed:articleTitle |
Transcription of the promoter of the rat NF-1 gene depends on the integrity of an Sp1 recognition site.
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pubmed:affiliation |
European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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