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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1990-10-22
|
| pubmed:abstractText |
In vivo administration of chloroquine to rats caused an increase in the pH of hepatocyte lysosomes within 1 hr after administration with a return to baseline pH values by 3 hr; continued administration of chloroquine for up to 12 days was unaccompanied by any further changes in hepatocyte lysosomal pH. We interpret these data as evidence against a major role for an increase in the pH of hepatocyte lysosomes in CAC-induced phospholipidosis.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0006-2952
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
40
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1419-21
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2403396-Animals,
pubmed-meshheading:2403396-Chloroquine,
pubmed-meshheading:2403396-Hydrogen-Ion Concentration,
pubmed-meshheading:2403396-Injections, Intraperitoneal,
pubmed-meshheading:2403396-Liver,
pubmed-meshheading:2403396-Lysosomes,
pubmed-meshheading:2403396-Male,
pubmed-meshheading:2403396-Rats,
pubmed-meshheading:2403396-Rats, Inbred Strains
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Time-dependent effects of chloroquine on pH of hepatocyte lysosomes.
|
| pubmed:affiliation |
Gastroenterology Research Unit, Mayo Medical School, Rochester, MN 55905.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|